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Himanshu Gupta, Ph.D., MRSB

Himanshu Gupta, Ph.D., MRSB

  • Assistant Professor
    Institute of Applied Sciences & Humanities
  • Department

    Department of Biotechnology
  • Contact Details:

    Email :

    Contact Number :8152977415

  • Experience

    8 Years

  • Qualifications

    • Ph.D. (Biotechnology; 2010 – 2015), School of Life Science (SOLS), Manipal University, India.
    • MSc. (Animal Biotechnology; 2007 - 2009), Department of Animal Biotechnology, University of Hyderabad, India.
    • BSc. (Medical Laboratory Technology; 2003 - 2006), Institute of Rehabilitation Medicine & Allied Sciences, Guru Gobind Singh Indraprastha University, India.
  • Ph.D

    Thesis Supervised

  • Awarded/ Completed-

    Working 02

  • Postgraduate

    Thesis Supervised

  • Awarded/ Completed01

    Working 01

  • London School of Hygiene and Tropical Medicine (LSHTM), London, UK - Research fellow; September, 2019 to December, 2021.
  • Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain - Postdoctoral fellow; January, 2016 to July, 2019

Dr. Gupta’s research focuses on the development of novel tools for early malaria diagnosis, case management, and surveillance of malaria elimination activities by understanding important host and parasite factors.

He is also interested in using microRNAs (miRNAs) as a tool with machine learning approaches to detect different infectious diseases with generic symptoms such as fever, which may help in developing cost-effective and easily deployable diagnostic assays for patient care. Additionally, his lab is also assessing the potential of miRNAs in the context of cancer and retinal disorders.

Differentially expressed miR-3158-3p microRNA in severe malaria: from discovery to validation. Funded by SERB, New Delhi, India; Budget – 30,50340/- INR; Duration: 2022 – 2024; Principal Investigator.

  • Gilyazova I, Ivanova E, Gupta H, Mustafin A, Ishemgulov R, Izmailov A, Gilyazova G, Pudova E, Pavlov V, Khusnutdinova E. miRNA Expression Patterns in Early- and Late-Stage Prostate Cancer Patients: High-Throughput Analysis. Biomedicines. 2023; 11(11):3073. IF-4.7
  • Gupta A, Skjefte M, Muppidi P, Sikka R, Pandey M, Bharti PK, Gupta H. Unravelling the Influence of Host Genetic Factors on Malaria Susceptibility in Asian Populations. Acta Tropica. 2024, 249:107055. IF-2.7
  • Sikka R, Raina P, Soni R, Gupta H, Bhanwer AJS. Genomic profile of diabetic retinopathy in a north indian cohort. Mol Biol Rep (2023). IF-2.8
  • Gilyazova I, Asadullina D, Kagirova E, Sikka R, Mustafin A, Ivanova E, Bakhtiyarova K, Gilyazova G, Gupta S, Khusnutdinova E, Gupta H, Pavlov V. MiRNA-146a-A Key Player in Immunity and Diseases. Int J Mol Sci. 2023 Aug 14;24(16):12767. IF-5.6
  • Mukhi B, Gupta H, Punnath K, Anvikar AR, Srivastava B, Ghosh SK. Artemisinin-based combination therapy successfully treated two hyperparasitaemic Plasmodium falciparum cases. J Infect Dev Ctries. 2023 May 31;17(5):725-731. IF-1.9
  • Muppidi P, Wright E, Wassmer SC, Gupta H. Diagnosis of cerebral malaria: Tools to reduce Plasmodium falciparum associated mortality. Frontiers in Cellular and Infection Microbiology. 2023. 13, 95.
  • Gupta H, Nema S, Bharti PK. Time to stimulate Plasmodium vivax research in India: A way forward. Asian Pacific Journal of Tropical Medicine. 2023; 16 (1), 1-2. IF-3.1
  • Martiáñez-Vendrell X, Skjefte M, Sikka R, Gupta H. Factors Affecting the Performance of HRP2-Based Malaria Rapid Diagnostic Tests. Trop Med Infect Dis. 2022 Sept 25; 7(10): 265. IF-2.9
  • Mohanty S, Sahu PK, Pattnaik R, Majhi M, Maharana S, Bage J, Mohanty A, Mohanty A, Bendszus M, Patterson C, Gupta H, Dondorp AM, Pirpamer L, Hoffmann A, Wassmer SC. Evidence of Brain Alterations in Noncerebral Falciparum Malaria. Clin Infect Dis. 2022 Aug 24;75(1):11-18. IF-11.8
  • Sikka R, Bharti PK, Gupta H. microRNAs: An opportunity to overcome significant challenges in malaria detection and control. Curr Res Pharmacol Drug Discov. 2022;3:100115.
  • Gupta H*, Wassmer SC*. Harnessing the Potential of miRNAs in Malaria Diagnostic and Prevention. Front Cell Infect Microbiol. 2021;11:793954. *Corresponding authors IF-5.7
  • Sahu PK, Hoffmann A, Majhi M, Pattnaik R, Patterson C, Mahanta KC, Mohanty AK, Mohanty RR, Joshi S, Mohanty A, Bage J, Maharana S, Seitz A, Bendszus M, Sullivan SA, Turnbull IW, Dondorp AM, Gupta H, Pirpamer L, Mohanty S, Wassmer SC. Brain Magnetic Resonance Imaging Reveals Different Courses of Disease in Pediatric and Adult Cerebral Malaria. Clin Infect Dis. 2021 Oct 5;73(7):e2387-e2396. IF-11.8
  • Raina P, Sikka R, Gupta H, Matharoo K, Bali SK, Singh V, Bhanwer A. Association of eNOS and MCP-1 Genetic Variants with Type 2 Diabetes and Diabetic Nephropathy Susceptibility: A Case-Control and Meta-Analysis Study. Biochem Genet. 2021 Aug;59(4):966-996. IF-2.4
  • Gupta H*, Sahu PK, Pattnaik R, Mohanty A, Majhi M, Mohanty AK, Pirpamer L, Hoffmann A, Mohanty S, Wassmer SC*. Plasma levels of hsa-miR-3158-3p microRNA on admission correlate with MRI findings and predict outcome in cerebral malaria. Clin Transl Med. 2021 Jun;11(6):e396. *Corresponding authors IF-10.6
  • Gupta H*, Rubio M, Sitoe A, Varo R, Cisteró P, Madrid L, Cuamba I, Jimenez A, Martiáñez-Vendrell X, Barrios D, Pantano L, Brimacombe A, Bustamante M, Bassat Q, Mayor A. Plasma MicroRNA Profiling of Plasmodium falciparum Biomass and Association with Severity of Malaria Disease. Emerg Infect Dis. 2021 Feb;27(2):430-442. *Corresponding authors IF-11.8
  • Galatas B, Mayor A, Gupta H, Balanza N, Jang IK, Nhamussua L, Simone W, Cisteró P, Chidimatembue A, Munguambe H, Saúte F, Aide P, Bassat Q. Field performance of ultrasensitive and conventional malaria rapid diagnostic tests in southern Mozambique. Malar J. 2020 Dec 7;19(1):451. IF-3.0
  • Mukhi B, Gupta H*, Wassmer SC, Anvikar AR, Ghosh SK. Haplotype of RNASE 3 polymorphisms is associated with severe malaria in an Indian population. Mol Biol Rep. 2020 Nov;47(11):8841-8848. *Corresponding authors IF-2.8
  • Gupta H, Galatas B, Chidimatembue A, Huijben S, Cisteró P, Matambisso G, Nhamussua L, Simone W, Bassat Q, Ménard D, Ringwald P, Rabinovich NR, Alonso PL, Saúte F, Aide P, Mayor A. Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance. PLoS One. 2020;15(10):e0240174. IF-3.7
  • Huijben S, Macete E, Mombo-Ngoma G, Ramharter M, Kariuki S, Desai M, Shi YP, Mwangoka G, Massougbodji A, Cot M, Ndam NT, Uberegui E, Gupta H, Cisteró P, Aponte JJ, González R, Menéndez C, Mayor A. Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy. J Infect Dis. 2020 Jan 2;221(2):293-303. IF-6.4
  • Anvikar AR, van Eijk AM, Shah A, Upadhyay KJ, Sullivan SA, Patel AJ, Joshi JM, Tyagi S, Singh R, Carlton JM, Gupta H*, Wassmer SC*. Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India. Virulence. 2020 Jan 1;11(1):730-738. *Corresponding authors IF-5.2
  • Smith-Aguasca R, Gupta H, Uberegui E, Maquina M, Saute F, Paaijmans KP, Mayor A, Huijben S. Mosquitoes as a feasible sentinel group for anti-malarial resistance surveillance by Next Generation Sequencing of Plasmodium falciparum. Malar J. 2019 Oct 17;18(1):351. IF-3.0
  • Fonseca AM, González R, Bardají A, Jairoce C, Rupérez M, Jiménez A, Quintó L, Cisteró P, Vala A, Sacoor C, Gupta H, Hegewisch-Taylor J, Brew J, Ndam NT, Kariuki S, López M, Dobaño C, Chitnis CE, Ouma P, Ramharter M, Abdulla S, Aponte JJ, Massougbodji A, Briand V, Mombo-Ngoma G, Desai M, Cot M, Nhacolo A, Sevene E, Macete E, Menéndez C, Mayor A. VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy. Emerg Infect Dis. 2019 Oct;25(10):1851-1860. IF-11.8
  • Gupta H*, Galatas B, Matambisso G, Nhamussua L, Cisteró P, Bassat Q, Casellas A, Macete E, Aponte JJ, Sacoor C, Alonso P, Saúte F, Guinovart C, Aide P, Mayor A. Differential expression of var subgroups and PfSir2a genes in afebrile Plasmodium falciparum malaria: a matched case-control study. Malar J. 2019 Sep 23;18(1):326. *Corresponding authors IF-3.0
  • Marco-Hernández J, Camprubí D, Aylagas C, Gupta H, Castro P. Failure of intravenous artesunate treatment for Plasmodium falciparum malaria in a splenectomized traveller: A diagnostic challenge. Travel Med Infect Dis. 2019 Jul - Aug;30:142-143. IF-12.0
  • Rodríguez-Valero N, Camprubí D, García-Guijarro E, Llenas-García J, Alejo-Cancho I, Cisteró P, Mayor A, Muñoz J, Gupta H. Suspected quinine resistant P. falciparum severe malaria possibly acquired in Ivory Coast. Parasitol Int. 2018 Dec;67(6):684-687. IF-1.9
  • Gupta H, Macete E, Bulo H, Salvador C, Warsame M, Carvalho E, Ménard D, Ringwald P, Bassat Q, Enosse S, Mayor A. Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium falciparum, Mozambique, 2015. Emerg Infect Dis. 2018 Jan;24(1):40-48. IF-11.8
  • Martínez-Pérez G, Lansana DP, Omeonga S, Gupta H, Breeze-Barry B, González R, Bardají A, Sarukhan A, Goteh JDK, Tody E, Cisteró P, Benda B, Kercula JD, Kibungu FD, Meyer García-Sípido A, Bassat Q, Tarr-Attia CK, Mayor A. Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia. Malar J. 2018 Oct 11;17(1):357. IF-3.0
  • Gupta H, Matambisso G, Galatas B, Cisteró P, Nhamussua L, Simone W, Cunningham J, Rabinovich NR, Alonso P, Saute F, Aide P, Mayor A. Molecular surveillance of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum isolates from Mozambique. Malar J. 2017 Oct 16;16(1):416. IF-3.0
  • Galatas B, Nhamussua L, Candrinho B, Mabote L, Cisteró P, Gupta H, Rabinovich R, Menéndez C, Macete E, Saute F, Mayor A, Alonso P, Bassat Q, Aide P. In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections in Mozambican Adults: A Randomized, Placebo-controlled Trial with Implications for Elimination Strategies. Sci Rep. 2017 May 2;7(1):1356. IF-4.6
  • Gupta H, Chaudhari S, Rai A, Bhat S, Sahu PK, Hande MH, D'Souza SC, Shashikiran U, Satyamoorthy K. Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum. PLoS One. 2017;12(4):e0175702. IF-3.7
  • Magallón-Tejada A, Machevo S, Cisteró P, Lavstsen T, Aide P, Rubio M, Jiménez A, Turner L, Valmaseda A, Gupta H, De Las Salas B, Mandomando I, Wang CW, Petersen JE, Muñoz J, Gascón J, Macete E, Alonso PL, Chitnis CE, Bassat Q, Mayor A. Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria. PLoS Pathog. 2016 Nov;12(11):e1006011. IF-6.7
  • Gupta H, Dhunputh P, Bhatt AN, Satyamoorthy K, Umakanth S. Cerebral malaria in a man with Plasmodium vivax mono-infection: a case report. Trop Doct. 2016 Oct;46(4):241-245. IF-0.6
  • Gupta H, Srivastava S, Chaudhari S, Vasudevan TG, Hande MH, D'souza SC, Umakanth S, Satyamoorthy K. New molecular detection methods of malaria parasites with multiple genes from genomes. Acta Trop. 2016 Aug;160:15-22. IF-2.7
  • Gupta H, Afsal MP, Shetty SM, Satyamoorthy K, Umakanth S. Plasmodium vivax infection causes acute respiratory distress syndrome: a case report. J Infect Dev Ctries. 2015 Aug 29;9(8):910-3. IF-1.9
  • Gupta H, Jain A, Saadi AV, Vasudevan TG, Hande MH, D'Souza SC, Ghosh SK, Umakanth S, Satyamoorthy K. Categorical complexities of Plasmodium falciparum malaria in individuals is associated with genetic variations in ADORA2A and GRK5 genes. Infect Genet Evol. 2015 Aug;34:188-99. IF-3.2
  • Fernandes RC, Hasan M, Gupta H, Geetha K, Rai PS, Hande MH, D'Souza SC, Adhikari P, Brand A, Satyamoorthy K. Host genetic variations in glutathione-S-transferases, superoxide dismutases and catalase genes influence susceptibility to malaria infection in an Indian population. Mol Genet Genomics. 2015 Jun;290(3):1155-68. IF-3.1
  • Gupta H, Sakharwade SC, Angural A, Kotambail A, Bhat GK, Hande MH, D'Souza SC, Rao P, Kumari V, Saadi AV, Satyamoorthy K. Evidence for genetic linkage between a polymorphism in the GNAS gene and malaria in South Indian population. Acta Trop. 2013 Dec;128(3):571-7. IF-2.7
  • Saadi AV*, Gupta H*, Angural A, Dhanya SK, Mony S, Oberoi D, D'Souza SC, Sahoo RC, Hande MH, Gopinath PM, Satyamoorthy K. Single nucleotide polymorphisms of ADRB2 gene and their association with susceptibility for Plasmodium falciparum malaria and asthma in an Indian population. Infect Genet Evol. 2013 Dec;20:140-7. *equal contribution IF-3.2


  • Science of Defeating Malaria - A Leadership Course, Dakar, Senegal | June 18 to 23, 2023.
  • Malaria Gordon Conference 2023: Reinvigorating Malaria Control, Prevention and Treatment: From Bench to Bedside to Bednets, Rey Don Jaime Grand Hotel, Castelldefels, Barcelona, Spain | May 28 - June 2, 2023. Invited discussion leader


  • Johns Hopkins Future of Malaria Research Symposium | 12 Nov 2021, Virtual conference. “Assessing the use of microRNA as biomarkers of severity in P. falciparum malaria infection.”
  • Malaria Centre Retreat, Newnham College, Cambridge, 20 - 21 September 2021. “Assessing the use of microRNA as biomarkers of severity in P. falciparum malaria infection.”


  • EMBL Conference: BioMalPar XVI: Biology and Pathology of the Malaria Parasite. 18 - 19 May 2020, Virtual conference. “Assessing the use of microRNA as biomarkers of severity in P. falciparum malaria infection.” Himanshu Gupta, Praveen K. Sahu, Rajyabardhan Pattnaik, Sanjib Mohanty, Samuel C. Wassmer. Poster presentation.


  • ASTMH 68th Annual Meeting, National Harbor, Maryland, USA | November 20-24, 2019. “Impact of Mass Drug Administration with Dihydroartemisinin-Piperaquine on P. falciparum Antimalarial Resistance and Gametocytaemia.” Himanshu Gupta, Beatriz Galatas, Arlindo Chidimatembue, Pau Cisteró, Gloria Matambisso, Carlos Ruiz-Arenas, Lidia Nhamussua, Silvie Huijben, Wilson Simone, Quique Bassat, Juan Ramon González, Baltazar Candrinho, N Regina Rabinovich, Pedro Alonso, Francisco Saute, Pedro Aide, Alfredo Mayor. Poster presentation (LB-5294).


  • Dept. de Genètica i de Microbiologia. Facultat de  Biociències, Universitat Autònoma de Barcelona, Barcelona, Spain. March 2017. “Malaria: a story of the deadly disease”.
  • Keystone Symposium on “Malaria: From Innovation to Eradication” in Kampala, Uganda | 19 – 23 Feb, 2017. “Molecular surveillance of antimalarial and diagnostic resistance in Mozambican Plasmodium falciparum isolates: implications for elimination strategies”.  Himanshu Gupta, Gloria Matambisso, Beatriz Galatas, Lidia Nhamussua, Wilson Simone, Quique Bassat, Pau Cisteró, Silvie Huijben, Eusébio Macete, Jane Cunningham, Didier Ménard, Pascal Ringwald, N Regina Rabinovitch, Pedro Alonso, Franciso Saute, Pedro Aide, Alfredo Mayor. Poster presentation.


  • Dept. de Genètica i de Microbiologia. Facultat de  Biociències, Universitat Autònoma de Barcelona, Barcelona, Spain. May 2016. “Malaria: a story of the deadly disease”.


  • Gordon Research Conference: Translating Malaria Research to the Field, Girona, Spain | July 26-31, 2015. “Genetic and Epigenetic Variations may Influence Malaria Susceptibility.” Himanshu Gupta, Abdul Saadi Vahab, Manjunath H Hande, Sydney C D’Souza, K Satyamoorthy. Poster presentation.
  • National Institute of Immuno Haematology (ICMR), Mumbai, India: Genomics in Health and Disease & 40th annual conference of Indian Society of Human Genetics, January 28-30, 2015. “Genetic and Epigenetic Variations Can Influence Malaria Susceptibility.” Himanshu Gupta, Ayushi Rai, Manjunath H Hande, Sydney C D’Souza, Saadi Abdul Vahab, K Sataymoorthy. Poster presentation.


  • Manipal University, Manipal, India: Society of Biological Chemists (India) Coastal Karnataka Chapter symposium, October 25, 2014. “Genetic and Epigenetic variations in ABCB1 gene can modulate drugs response and malaria susceptibility”
  • Manipal University, Manipal, India: Manipal Research Colloquium, 11th- 12th, April, 2014. “Variants of GNAS and ADRB2 Genes modulate Susceptibility of Malaria and Asthma diseases”.


  • Christ University, Bangalore: 6th Annual KSTA Conference: Science and Technology for Promoting Innovative Research and Development, December 21 and 22, 2013. “Variants of ADORA2A and GRK5 Genes modulate Susceptibility of Malaria in a South Indian Population”. Himanshu Gupta, Abdul Saadi Vahab, Manjunath H Hande, Sydney C D’Souza, PM Gopinath, K Satyamoorthy. Poster presentation.
  • Amrita Vishwa Vidyapeetham (University), Kollam: Amrita BioQuest-2013, International Conference on Biotechnology for Innovative Application, August 10-14, 2013. “Variants of ADORA2A and GRK5 Genes modulate Susceptibility of Malaria in a South Indian Population”. Himanshu Gupta, Abdul Saadi Vahab, Manjunath H Hande, Sydney C D’Souza, PM Gopinath, K Satyamoorthy. Poster presentation.


  • Participated in Manipal University, Manipal, India: Genomics, Genetic Diseases and Diagnostics, February 14-16, 2011.


  • Participated in Short Term Training Programme on Designing and Synthesis of Peptide Antigens for Diagnosis” organized by Division of Animal Biotechnology, Indian Veterinary Research Institute, Bareilly, 10-17 February, 2010.


  • Participated in “International Conference on Novel Updates in Reproductive Biology and Comparative Endocrinology and The 27th Annual Meeting of the Society for Reproductive Biology and Comparative Endocrinology (SRBCE-XXVII)” at University of Hyderabad, Hyderabad, 18-21 September, 2009.


  • Participated in “EU-sponsored NanoBioSaccharides (NBS) Dissemination Conference” at University of Hyderabad, Hyderabad, 18-19 September, 2008.
  • Royal Society of Biology, UK - Member elect (MRSB) (from January 2020)
  • Editorial/ Journal topic board member
    • PLoS ONE (September/2022 - present)
    • Frontiers in Cellular and Infection Microbiology (April/2022 - present)
    • Journal of Applied Genetics (December/2020 - present)
    • Tropical Medicine and Infectious Disease (Aug/2020 - present)
    • Molecular Biology Reports Journal (Sep/2018 - present)


  • 2013: 1st prize for poster presentation at 6th Annual KSTA Conference: Science and Technology for Promoting Innovative Research and Development Bangalore, India.
  • 2015:  Young scientist award (travel and registration) from Science and Engineering Research Board (SERB) (Application No.- ITS/2259/2015-2016) to attend Gordon Research Conference and Seminar “Translating Malaria Research to the Field”, Girona, Spain
  • 2016:  European Commission Seal of Excellence for Horizon 2020’s Marie Skłodowska-Curie actions call H2020-MSCA-IF-2016
  • 2017:  Bill and Melinda Gates Foundation Global Health Travel Award to attend Keystone Symposium on “Malaria: From Innovation to Eradication” in Kampala, Uganda.

Competitive Fellowships/All India Entrance Exam Cleared

  • January, 2017 to January, 2019 – Overseas Postdoctoral Fellowship, Science and Engineering Research Board, DST, India.
  • November, 2010 to October, 2015 – Doctoral Fellowship, Manipal University, India.
  • 2007- Cleared all India entrance exam of University of Hyderabad for M.Sc. Animal Biotechnology.
  • 2007- Cleared all India entrance exam of Jamia Hamdard University for M.Sc. Biochemistry.
  • 2003- Cleared all India entrance exam of GGSIP University for B.Sc. MLT.

International Thesis Supervision

  • Master thesis (LSHTM, UK): Investigating extracellular vesicle microRNAs derived from human brain endothelial cells after co-culturing with P. falciparumSabeeya Khan.
  • Master thesis (LSHTM, UK): Assessment of extracellular vesicle microRNA cargo as a potential tool for the diagnosis of malaria-associated ARDS - Pranavi Muppidi.
  • Master thesis (LSHTM, UK): The quest for diagnostic and prognostic markers in cerebral malaria - Emily Wright.
  • Master thesis (ISGlobal, Spain): Identification of Gene Targets of microRNAs to be used as Biomarkers in Severe Malaria - Allison Brimacombe.

Scientific Activities

  • Peer reviewer -( more than 50 manuscripts
    • Nature Communications
    • Frontiers in Cellular and Infection Microbiology
    • Antimicrobial Agents and Chemotherapy journal
    • Scientific Reports
    • Journal of Clinical Microbiology
    • iScience
    • The American Journal of Tropical Medicine and Hygiene
    • Malaria Journal
    • Journal of Applied Genetics
    • Plos One, etc.

Miscellaneous Courses

  • Certificate course in GOOD CLINICAL PRACTICE from NIDA Clinical Trials Network (April/2020 – April/2023).
  • Certificate course in Biostatistics, Epidemiology and Research Methodology conducted by Department of Statistics, Manipal University, Manipal.
  • Certificate course in Bioinformatics conducted by Department of Bioinformatics, School of Life Sciences, Manipal University, Manipal.
  • Twitter: @hgupta84; @hapyresearchers
  • Google scholar: Click here