GLA

Faculty

Dr. Jyoti Gupta

Assisitant Professor - Institute of Applied Sciences & Humanities

Department

Department of Biotechnology

Experience

10 Years

Dr. Jyoti Gupta

Ph.D Thesis Supervised

3

Working

Postgraduate Thesis Supervised

2

Awarded/
Completed

Qualifications

  • Ph.D.

Publication

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  • Gupta, J. and Kumar, R. (2026) ‘A comprehensive review on artificial intelligence driven approaches for vaccine development: Current advances, challenges, and future prospects’, Current Research in Translational Medicine, p. 103577. https://www.sciencedirect.com/science/article/abs/pii/S2452318626000140
  • Tiwari, P., Saraswat, I. and Gupta, J. (2026) ‘Insight into the biology of hepatitis B virus and recent therapeutic approaches’, Current Microbiology, 83(3), p. 151. https://pubmed.ncbi.nlm.nih.gov/41642349/
  • Kumar, S., Mehta, S., Gupta, J., Anand, G., Hooda, P., Kumar, A., Sehgal, D. and Surjit, M. (2025) ‘Viral helicase and methyltransferase promote genotype one-hepatitis E virus internal ribosome entry site-like element activity’, npj Viruses, 3(1), p. 77. https://pubmed.ncbi.nlm.nih.gov/41225140/
  • Saraswat, I., Goel, A. and Gupta, J. (2026) ‘Nanotechnology meets phytotherapy: A comprehensive review of berberine in cancer’, Mini-Reviews in Medicinal Chemistry. https://pubmed.ncbi.nlm.nih.gov/41588954/
  • Saraswat, I., Goel, A. and Gupta, J. (2026) ‘Herbal remedies for hepatic diseases: A review of medicinal herbs in the treatment of liver disorders’, Chinese Herbal Medicines. https://www.sciencedirect.com/science/article/pii/S1674638426000171
  • Sharma, P., Vashistha, M., Jaglana, A.B., Gupta, J., Kapoor, P., Bhutani, K., Virmani, N., Bera, B.C., Vaid, R.K. and Anand, T. (2025) ‘Micro and nanotechnological interventions for improved and targeted bacteriophage’, Environmental Chemistry Letters. https://link.springer.com/article/10.1007/s10311-025-01881-0
  • Kumar, R., Borkotoky, S., Gupta, R., Gupta, J., Maji, S., Tiwari, S., Tyagi, R.K. and Oliva, B. (2025) ‘Stabilizing the shield: C-terminal tail mutation of HMPV F protein for enhanced vaccine design’, BioMedInformatics, 5(3), p. 47. https://www.mdpi.com/2673-7426/5/3/47
  • Gupta, R., Begum, M.Y., Kumar, R., Gupta, J., Nagraik, R., Panda, S.P., Abomughaid, M.M., Lakhanpal, S., Osmani, R.A.M. and Jha, N.K. (2025) ‘The ubiquitin–proteasome system in brain disorders: Pathogenic pathways, post-translational tweaks, and therapeutic frontiers’, Journal of Neuroimmune Pharmacology, 20(1), p. 105. https://pubmed.ncbi.nlm.nih.gov/41264052/
  • Kumar, R., Maji, S., Tiwari, S., Misra, J., Gupta, J., Kumar, N., Gupta, R. and Jha, N.K. (2025) ‘Precision vaccine design targeting the prefusion state of viral glycoproteins: Advances in structural vaccinology’, Biochemical Pharmacology, p. 117349. https://pubmed.ncbi.nlm.nih.gov/40972736/
  • Saraswat, I., Goel, A. and Gupta, J. (2024) ‘An in-depth review on Argemone mexicana in the management of liver health and liver cancer’, Anti-Cancer Agents in Medicinal Chemistry. doi:10.2174/0118715206307964240821051756. https://pubmed.ncbi.nlm.nih.gov/39225208/
  • Gupta, J. and Saraswat, I. (2025) ‘Modulation of the unfolded protein response by viruses: Mechanistic insights and implications for viral pathogenesis’, Current Protein and Peptide Science (Accepted).
  • Ansari, S., Gupta, N., Verma, R., Singh, O.N., Gupta, J., Kumar, A., Kumar, M., Yadav, A., Tiwari, B.M., Periwal, N., Sood, V., Mani, S., Awasthi, A., Shalimar, B.N., Ranjith-Kumar, C.T. and Surjit, M. (2023) ‘Antiviral activity of the human endogenous retrovirus-R envelope protein against SARS-CoV-2’, EMBO Reports, p. e55900. https://pmc.ncbi.nlm.nih.gov/articles/PMC10328075/
  • Gupta, J., Irfan, M., Ramgir, N., Muthe, K.P., Debnath, A.K., Ansari, S., Gandhi, J., Ranjith-Kumar, C.T. and Surjit, M. (2022) ‘Antiviral activity of zinc oxide nanoparticles and tetrapods against the hepatitis E and hepatitis C viruses’, Frontiers in Microbiology. doi:10.3389/fmicb.2022.881595. https://pubmed.ncbi.nlm.nih.gov/35814711/
  • Gupta, J., Kaul, S., Srivastava, A., Ghosh, S., Sharma, C., Banerjee, M., Shalimar, Nayak, B., Ranjith-Kumar, C.T. and Surjit, M. (2020) ‘Expression and characterization of hepatitis E virus-like particles (VLP) expressed in Pichia pastoris’, Frontiers in Microbiology. doi:10.3389/fmicb.2020.00141. https://pubmed.ncbi.nlm.nih.gov/32117160/
  • Gupta, J., Kumar, A. and Surjit, M. (2021) ‘Production of a hepatitis E vaccine candidate using the Pichia pastoris expression system’, Methods in Molecular Biology, 2415, pp. 117–131. https://pubmed.ncbi.nlm.nih.gov/34918244/
  • Gupta, J., Pathak, M., Misra, S. and Misra-Bhattacharya, S. (2019) ‘CpG enhances the immunogenicity of heterologous DNA prime/protein boost vaccination employing heavy chain myosin of Brugia malayi in BALB/c mice’, Parasitology Research. doi:10.1007/s00436-019-06318-6. https://pubmed.ncbi.nlm.nih.gov/31069533/
  • Anang, S., Kaushik, N., Hingane, S., Kumari, A., Gupta, J., Asthana, S., Shalimar, Nayak, B., Ranjith-Kumar, C.T. and Surjit, M. (2018) ‘Potent inhibition of hepatitis E virus release by a cyclic peptide inhibitor of the interaction between viral open reading frame 3 protein and host tumor susceptibility gene 101’, Journal of Virology, 92(20), p. e00684-18. https://pubmed.ncbi.nlm.nih.gov/30068652/
  • Misra, S., Gupta, J. and Misra-Bhattacharya, S. (2017) ‘RNA interference mediated knockdown of Brugia malayi UDP-galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae’, Parasites & Vectors. doi:10.1186/s13071-017-1967-1. https://pubmed.ncbi.nlm.nih.gov/28103957/
  • Gupta, J., Misra, S. and Misra-Bhattacharya, S. (2016) ‘Immunization with Brugia malayi myosin as heterologous DNA prime protein boost induces protective immunity against B. malayi infection in Mastomys coucha’, PLoS ONE, 11(11), p. e0164991. https://pubmed.ncbi.nlm.nih.gov/27828973/
  • Misra, S., Valicherla, G., Shahab, M., Gupta, J., Gayen, J. and Misra-Bhattacharya, S. (2016) ‘UDP-galactopyranose mutase, a potential drug target against human pathogenic nematode Brugia malayi’, Pathogens and Disease, 74(6). https://pubmed.ncbi.nlm.nih.gov/27465638/
  • Gupta, J., Pathak, M., Misra, S. and Misra-Bhattacharya, S. (2015) ‘Immunogenicity and protective efficacy of Brugia malayi heavy chain myosin as homologous DNA, protein and heterologous DNA/protein prime boost vaccine in rodent model’, PLoS ONE, 10, e0142548. https://pubmed.ncbi.nlm.nih.gov/26560102/
  • Shukla, R., Gupta, J., Shukla, P., Dwivedi, P., Tripathi, P., Misra-Bhattacharya, S.M. and Mishra, P.R. (2015) ‘Chitosan coated alginate microparticles for the oral delivery of antifilarial drugs and combinations for intervention in Brugia malayi induced lymphatic filariasis’, RSC Advances, 5, pp. 69047–69056. https://pubs.rsc.org/en/content/articlelanding/2015/ra/c5ra06982c/unauth
  • Misra, S., Singh, L.K., Priyanka, Gupta, J., Misra-Bhattacharya, S. and Katiyar, D. (2015) ‘Synthesis and biological evaluation of 4-oxycoumarin derivatives as a new class of antifilarial agents’, European Journal of Medicinal Chemistry, 4, pp. 211–217. https://pubmed.ncbi.nlm.nih.gov/25768703/
  • Sashidhara, K.V., Avula, S.R., Doharey, P.K., Singh, L.R., Balaramnavar, V.M., Gupta, J., Misra-Bhattacharya, S., Rathaur, S., Saxena, A.K. and Saxena, J.K. (2015) ‘Designing and synthesis of selective and high-affinity chalcone-benzothiazole hybrids as Brugia malayi thymidylate kinase inhibitors: In vitro validation and docking studies’, European Journal of Medicinal Chemistry, 103, pp. 418–428. https://pubmed.ncbi.nlm.nih.gov/26383126/
  • Naresh, J.G., Gupta, J., Bhattacharya, S.M., Rajendran, S.M., Awasthi, S.K. and Narender, T. (2013) ‘Antifilarial activity of constituents of Calophyllum inophyllum and their derivatives’, Natural Product Communications, 8(6), pp. 803–804. https://journals.sagepub.com/doi/abs/10.1177/1934578X1300800630
  • Gupta, J., Misra, S., Mishra, S.K., Srivastava, S., Srivastava, M.N., Lakshmi, V. and Misra-Bhattacharya, S. (2012) ‘Antifilarial activity of marine sponge Haliclona oculata against experimental Brugia malayi’, Experimental Parasitology, 130(4), pp. 449–455. https://www.sciencedirect.com/science/article/abs/pii/S0014489412000264
  • Nag, J.K., Shrivastava, N., Gupta, J. and Misra-Bhattacharya, S. (2012) ‘Recombinant translation initiation factor-1 of Wolbachia is an immunogenic excretory secretory protein that elicits Th2 mediated immune protection against Brugia malayi’, Comparative Immunology, Microbiology and Infectious Diseases, 36, pp. 25–38. https://www.sciencedirect.com/science/article/abs/pii/S014795711200104X
  • Kushwaha, S., Singh, P.K., Gupta, J., Soni, V.K. and Misra-Bhattacharya, S. (2012) ‘Recombinant trehalose-6-phosphate phosphatase of Brugia malayi cross-reacts with human Wuchereria bancrofti immune sera and engenders a robust protective outcome in mice’, Microbes and Infection, 14, pp. 1330–1339. https://www.sciencedirect.com/science/article/pii/S128645791200216X
  • Sashidhara, K.V., Singh, S.P., Misra, S., Gupta, J. and Misra-Bhattacharya, S. (2012) ‘Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi’, European Journal of Medicinal Chemistry, 50, pp. 230–235. https://pubmed.ncbi.nlm.nih.gov/22348826/

Conferences / Seminar / Workshop

+
  • Jyoti Gupta and Milan Surjit. Exploring the antiviral potential of Zinc Oxide nanoparticles and tetrapods against the Hepatitis E and Hepatitis C viruses. “International Union of Biochemistry and Molecular Biology-2022 at Regional Center for Biotechnology, Faridabad, India.

Subjects Taught

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Molecular diagnostics and vaccinology, virology and cancer biology, animal and plant physiology

Research Interest

+
Vaccine and drug development against viral disease
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